Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation
نویسندگان
چکیده
منابع مشابه
Antiimmunoglobulin-treated B cells respond to a B cell differentiation factor for IgG1
We have determined whether B cells previously activated by anti-Ig (anti-Ig blasts) are responsive to lymphokines that induce isotype switching. Culture of anti-Ig blasts with a mixture of lymphokines, including BSF-1, resulted in marked secretion of IgM and IgG1, but not other IgG isotypes. The IgG1 response of anti-Ig blasts to lymphokines was 13-fold greater than was observed with splenic B ...
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Ag-primed B cells that result from an immune response can form either memory B cells or Ab-secreting plasma cells; however, the molecular machinery that controls this cellular fate is poorly understood. In this study, we show that activated B cell factor-1 (ABF-1), which encodes a basic helix-loop-helix transcriptional repressor, participates in this regulation. ABF-1 was prevalently expressed ...
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Plasma cells are antibody-producing cells and represent the developmental end point of the B-cell lineage. Over the last few years, major progress has been made in understanding the transcriptional regulation of B-cell to plasmacell transition. Two transcription factors, Pax5 and Blimp1, are responsible for the development and maintenance of B-cell and plasma-cell identity, respectively. Both f...
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15 صفحه اولDifferential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells.
Along humoral immune responses, different stimuli drive the differentiation of B lymphocytes to Ig-secreting plasma cells in discrete microenvironments. The Blimp-1 transcription factor is up-regulated early during the transition of mature B cells to IgM-secreting plasma cells. In the present study, we have examined the requirement of Blimp-1 in plasma cell formation after both T cell-independe...
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ژورنال
عنوان ژورنال: Immunity
سال: 2013
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2013.06.011